Symmetrel (Amantadine Hydrochloride)- FDA

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Most hydroxides are insoluble (except with alkali metals as in NaOH or KOH). Salts of doubly charged ions CO32- S2- PO43- mostly are insoluble.

Salts of singly charged versions of these are soluble (HCO3- H2PO4- ) Reactions where soluble compounds react to form insoluble ones are called precipitation reactions. For a table of solubilities click here Back to Top Solubility Product Constant Since salts dissolve into electrically charged species (as do acids and bases) they fall in the general category called electrolytes.

We can perform equilibrium type calculations as we did previously. Symmetrel (Amantadine Hydrochloride)- FDA to Top Common Ion Effect The solubility post rape an ionic compound in a solution which already contains one of the ions in that compound is reduced. Example What is the Prazosin HCl (Minipress)- FDA of PbCl2 in 1.

If we add Symmetrel (Amantadine Hydrochloride)- FDA H2SO4 type 1 complex regional pain syndrome make a 1. Back to Top Effect of pH on Solubility Many weakly soluble ionic compounds have solubilities which depend on Symmetrel (Amantadine Hydrochloride)- FDA pH of the solution.

Much larger solubility than than in pure water. Since the second equilibrium (above) goes to completion, we can use the summed equilibrium. Another example: In this one, we can not assume that the intermediate concentrations are negligibly small. The solubility of the compound is determined as the concentration of unionised compound in solution when the measured pH slope is interpolated to zero. Method for determining solubility of a chemical compoundThe present invention relates to a method for determining the solubility of a chemical compound.

In particular, the present invention relates to method Symmetrel (Amantadine Hydrochloride)- FDA more rapid determination of the solubility of an organic chemical compound having one or more acidic or basic groups.

The determination of the solubility of a chemical compound is a routine requirement in analytical chemistry laboratories. Such determination is for example, commonly required in the development and assessment of new pharmaceutical and agrochemical compounds, many of which contain Fortaz (Ceftazidime)- FDA or more acidic or basic groups that react with hydrogen ions in aqueous solution.

Traditional methods of determining solubility rely on the addition of a known mass of chemical compound to a known volume of distilled water at a defined pH. The resulting solution is agitated (e. Samples of the equilibrated solution are then removed and the solubility determined by known analytical methods.

A problem with such traditional methods is that it is not unusual for an extended period of time, sometimes in excess of 48 hours, to be required for an equilibrium state to be reached. Thus, the Symmetrel (Amantadine Hydrochloride)- FDA is undesirably slow. In addition, over such an extended time period it is not uncommon for environmental factors to affect the test solution.

For example, atmospheric carbon dioxide may dissolve in the solution to produce carbonic acid, thereby potentially affecting the pH thereof. Alternatively, the chemical compound itself may be subject to environmental degradation (e. Overall, it is therefore desirable both from an efficiency and accuracy standpoint to provide a method for more rapid determination of solubility.

A pH-metric method of determining solubility has Symmetrel (Amantadine Hydrochloride)- FDA described in the literature: 'pH-metric Solubility. Solubility-pH Profile from Bjerrum Plots. Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods: Pharmaceutical Research, 2000, 17: pages Symmetrel (Amantadine Hydrochloride)- FDA 89.

In practice, however this method still typically requires from six to eight hours to conduct and therefore represents only a partial advance over the traditional methods. The Applicant has now developed a method of determining the solubility of chemical compounds containing one or more acidic or basic groups that is much faster than both traditional and pH-metric methods.

A typical solubility determination can be conducted in less than an hour (e. The method may Symmetrel (Amantadine Hydrochloride)- FDA used for even poorly soluble chemical compounds and is readily susceptible to automation.

Additionally, the method of the present invention does not necessarily require the use of co-solvents as are commonly used in more traditional methods, particularly when assessing compounds of low solubility. The article 'General treatment of pH solubility profiles of weak acids and bases.

Evaluation of thermodynamic parameters from the temperature dependence of solubility profiles applied to a zwitterionic compound: International Journal of Pharmaceutics, 1985, 25: pages 135-145 describes a method of solubility determination that requires 3-5 days for an equilibrium state to be reached. It is an object of the present invention to provide a method of determining the solubility of chemical compounds containing one or more acidic or basic groups that is more efficient than known methods.



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